Dr. Otávio Melo - Wave-Regen - Instituto Regenius

Wave-Regen

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O QUE É ?

O programa Wave-Regen do Instituto Regenius utiliza como princípio a propagação de ondas de choque mecânicas, e não tem nenhuma semelhança com o choque elétrico utilizado em métodos convencionais.

Trata-se de um tratamento não invasivo, por meio do qual estímulos físicos geram rápida variação de pressão sobre o local tratado, e que promove, dessa maneira, a formação de novos vasos sanguíneos, liberação de fatores de crescimento, melhora da nutrição e oxigenação, regeneração dos tecidos, redução da dor entre diversos benefícios.

COMO FUNCIONA ?

O método pode ser dividido em 2 tipos principais : ondas radiais ou focais. A aplicação pode ter intensidades baixa, média ou ainda com alta energia, que irá se propagar a partir da pele, através do tecido até a região da dor ou lesão.


As ondas radiais são mais difusas e se espalham pelos tecidos superficiais, enquanto as ondas focais se concentram em um ponto a uma determinada profundidade. Em alguns casos para obter resultados melhores, podem ser aplicados ambas as formas para o mesmo tratamento, alcançando efeitos biológicos superficiais e profundos de maneira simultânea.


O número de aplicações pode variar de acordo com o tempo e grau da lesão a ser tratada, e características individuais de cada pessoa.
Wave Regen Braco
Dr Otavio - Wave Regen

PARA QUE SERVE ?

É indicado para lesões e inflamações agudas e crônicas dos tendões, músculos e outros tecidos tanto do sistema locomotor quanto em outros órgãos do corpo que tenham a nutrição sanguínea prejudicada por algum motivo.

Exemplos de indicações são o esporão de calcâneo, calcificações, tendinites, epicondilites em praticamente todas as regiões do corpo, além de inflamações e feridas que não foram solucionadas pelos tratamentos habituais. 

Também se beneficiam portadores de dores crônicas como nas artroses, compressão de nervos ou no atraso da consolidação óssea, e as fraturas por stress (sobrecarga).

Estudos mais recentes mostram ainda eficácia para condições como angina, disfunção erétil e até lesões neurológicas.

Logo abaixo você encontra uma vasta relação de estudos científicos que demonstram a eficácia comprovada desse método de tratamento nas mais diversas condições clínicas.

Atualmente não apenas a ortopedia, como a clínca da dor, neurologia, cardiologia, dermatologia, angiologia, e urologia já beneficiam seus pacientes com o tratamento regenerativo promovido pelas ondas de choque e programa Wave-Regen.

BENEFÍCIOS

Diversos artigos científicos comprovam a eficiência do método aplicado no programa Wave-Regen. Logo abaixo você encontrará mais informações sobre os trabalhos de pesquisa publicados recentemente a respeito do assunto na literatura médica internacional.

O tratamento tem beneficiado milhões de pessoas no mundo, não só aquelas com dores agudas e crônicas nas articulações da coluna, ombro, cotovelo, punho, mão, quadril, joelho, tornozelo, bacia; mas também com problemas de circulação, dores de origem muscular e até mesmo neurológicas.

Devido a suas características físicas e biológicas, há evidências de que atue também para aliviar a espasticidade como nos casos das paralisias, acidentes vasculares cerebrais, doença de Parkinson, cicatrizes distróficas, e muitas outras condições. Caso tenha dúvidas, entre em contato, clicando no botão.
REFERÊNCIAS BIBLIOGRÁFICAS - EVIDÊNCIAS CIENTÍFICAS

REGULAMENTAÇÃO, RECOMENDAÇÕES E CONSENSOS
1. Parecer CREMERJ 188/2008 
2. Parecer CRM-DF 82/2016
3. Parecer CFM 44/2016
INDICAÇÕES E MECANISMOS DE AÇÃO
1. Consensus Statement on ESWT Indications and Contraindications. ISMST, 2016

2. The role of extracorporeal shockwave treatment in musculoskeletal disorders. Journal of Bone and Joint Surgery - American Volume. 2018,100:3(251-263) doi : 10.2106/JBJS.17.00661
3. Shock wave as biological therapeutic tool: From mechanical stimulation to recovery and healing, through mechanotransduction. International Journal of Surgery. 2015,24(147-153). doi : 10.1016/j.ijsu.2015.11.030
4. Effect of Shockwave Treatment for Management of Upper and Lower Extremity Musculoskeletal Conditions: A Narrative Review. PM and R.. 2018,10:12(1385-1403). 10.1016/j.pmrj.2018.05.007
5. Efficacy and safety of extracorporeal shock wave therapy for orthopedic conditions: A systematic review on studies listed in the PEDro database. British Medical Bulletin. 2015,11:1(115-138). doi : 10.1093/bmb/ldv047
DORES CRÔNICAS, FADIGA, MÚSCULOS
1. Update on the efficacy of extracorporeal shockwave treatment for myofascial pain syndrome and fibromyalgia. International Journal of Surgery. 2015,24(201-206). doi : 10.1016/j.ijsu.2015.08.083
2. Effect of a Single Administration of Focused Extracorporeal Shock Wave in the Relief of Delayed-Onset Muscle Soreness: Results of a Partially Blinded Randomized Controlled Trial. Archives of Physical Medicine and Rehabilitation. 2017,98:5(923-930). doi : 10.1016/j.apmr.2016.11.013
3. EXTRACORPOREAL SHOCKWAVE TERAPY TO TREAT CHRONIC MUSCLE INJURY. Acta Ortopédica Brasileira. 2015, 23:5(247-250). doi : 10.1590/1413-785220152305142211
4. The influence of medical shockwaves on muscle activation patterns and performance in healthy athletes: a preliminary report. ISMTS 2015 COngress.
5. The effect of low intensity shockwave treatment (Li-SWT) on human myoblasts and mouse skeletal muscle. BMC Musculoskeletal Disorders. 2017,18:1(1-13). doi : 10.1186/s12891-017-1879-4
6. The influence of medical shockwaves on muscle activation patterns and performance in healthy athletes : a preliminary report. ISMST 2015 Congress.
TENDINITES E ENTESITES
1. ESWT and nutraceutical supplementation (Tendisulfur Forte) vs ESWT-only in the treatment of lateral epicondylitis, Achilles tendinopathy, and rotator cuff tendinopathy: a comparative study. Journal of Drug Assessment, 2019,8:1(77-86). doi : 10.1080/21556660.2019.1605370
2. Shockwave therapy in the treatment of enthesopathies. Acta Balneologica. 2014,61:2
3. Efficacy of extracorporeal shock wave therapy for knee tendinopathies and other soft tissue disorders: a meta-analysis of randomized controlled trials. BMC Musculoskeletal Disorders. 2018,19:1. doi : 10.1186/s12891-018-2204-6
4. The biological effects of extracorporeal shock wave therapy (eswt) on tendon tissue. Muscles, Ligaments and Tendons Journal 2012,2:1(33-37). 
ARTROSES, OSTEONECROSE E OSTEOPOROSE - REGENERAÇÃO ÓSSEA
1. Effects of shock wave therapy on glycosaminoglycan expression during bone healing. International Journal of Surgery. 2015,24(120-123) doi : 10.1016/j.ijsu.2015.09.065
2. Osteogenetic effect of extracorporeal shock waves in human. International Journal of Surgery. 2015,24(115-119). doi : 10.1016/j.ijsu.2015.09.068
3. Shockwave Targeting on Subchondral Bone Is More Suitable than Articular Cartilage for Knee Osteoarthritis. International Journal of Medical Sciences. 2019,16:1(156-166). doi : 10.7150/ijms.26659
4. Extracorporeal shockwave therapy enhances expression of Pdia-3 which is a key factor of the 1α,25-dihydroxyvitamin D 3 rapid membrane signaling pathway in treatment of early osteoarthritis of the knee. International Journal of Medical Sciences. 2017,14:12(1220-1230). doi : 10.7150/ijms.20303
5. Short-term effects of extracorporeal shock wave therapy on bone mineral density in postmenopausal osteoporotic patients. Osteoporosis International. 2017,28:10(2945-2953). 10.1007/s00198-017-4136-7
6. Biological mechanism of shockwave in bone. International Journal of Surgery. 2015,24(143-146). http://dx.doi.org/10.1016/j.ijsu.2015.06.059
COLUNA E TRONCO
1. Estudo prospectivo, comparativo, randomizado, duplamente coberto, controlado com placebo sobre a eficácia das ondas de choque no tratamento da síndrome dolorosa miofascial das regiões lombar e glútea. Tese. FMUSP, 2018.
2. High- versus low-energy extracorporeal shockwave therapy for myofascial pain syndrome of upper trapezius A prospective randomized single blinded pilot study. Medicine. 2018,97:28. doi : 10.1097/MD.0000000000011432
3. Extracorporeal shock-wave therapy for treating chronic pelvic pain syndrome: A feasibility study and the first clinical results. BJU International. 2008,102:8(976-980). 10.1111/j.1464-410X.2008.07742.x
OMBRO

1. Analgesic effect of extracorporeal shock-wave therapy for frozen shoulder: A randomized controlled trial protocol. 2020, 99:31
2.Comparing the effectiveness of medium- and high-dose extracorporeal shockwave therapy against calcific tendonitis of the rotator cuff. Journal of Physics: Conference Series. 2018,1073:4. doi : 10.1088/1742-6596/1073/4/042025
3.Individualised radial extracorporeal shock wave therapy (rESWT) for symptomatic calcific shoulder tendinopathy: A retrospective clinical study. BMC Musculoskeletal Disorders. 2017,18:1.  doi : 10.1186/s12891-017-1873-x
4. Current knowledge on evidence-based shockwave treatments for shoulder pathology. International Journal of Surgery. 2015,24(171-178). doi : 10.1016/j.ijsu.2015.08.079
5. Effects of high- and low-energy radial shock waves therapy combined with physiotherapy in the treatment of rotator cuff tendinopathy: a retrospective study. Disability and Rehabilitation. 2018,40:21(2488-2494). doi : 10.1080/09638288.2017.1336650
6. The effectiveness of extracorporeal shockwave treatment in subacromial impingement syndrome and its relation with acromion morphology. Acta Orthopaedica et Traumatologica Turcica. 2018,52:1(17-21). doi : 10.1016/j.aott.2017.10.007
7. Comparative outcomes of extracorporeal shockwave therapy for shoulder tendinitis or partial tears of the rotator cuff in athletes and non-athletes: Retrospective study. International Journal of Surgery 2018,51(184-190)
8. The efficacy of radial extracorporeal shockwave therapy in shoulder adhesive capsulitis: A prospective, randomised, double-blind, placebo-controlled, clinical study. European Journal of Physiotherapy. 2016,18:1(63-76). doi : 10.3109/21679169.2015.1119887
9. Electromagnetic transduction therapy and shockwave therapy in 86 patients with rotator cuff tendinopathy: A prospective randomized controlled trial. Electromagnetic Biology and Medicine. 2018,37:4(175-183). 10.1080/15368378.2018.1499030
10. The effectiveness of extracorporeal shockwave therapy for frozen shoulder in patients with diabetes: randomized control trial. Journal of Physical Therapy Science. 2019,31:7(493-497). doi : 10.1589/jpts.31.493
11. Effects of Eccentric Exercise and Extracorporeal Shock Wave Therapy on Rehabilitation of Patients with Noncalcific Rotator Cuff Tendinopathy. Clinical Research on Foot & Ankle. 2017,5:1(1-7)  doi : 10.4172/2329-910x.1000222
COTOVELO

1. Effect of extracorporeal shock wave for tennis elbow: A protocol for systematic review of randomized controlled trial. Medicine (United States) 2019, 98:7(4-7). doi : 10.1097/MD.0000000000014517
2.  Comparison of the Effectiveness of Shockwave Therapy with Selected Physical Therapy Procedures in Patients with Tennis Elbow Syndrome. Ortopedia Traumatologia Rehabilitacja. 2018,4:6(301-311) doi : 10.5604/01.3001.0012.6464
3. Lateral epicondylitis: This is still a main indication for extracorporeal shockwave therapy. International Journal of Surgery. 2015,24. doi : 10.1016/j.ijsu.2015.09.034
4. Efficacy of low-energy extracorporeal shockwave therapy and a supervised clinical exercise protocol for the treatment of chronic lateral epicondylitis: A randomised controlled study. Hong Kong Physiotherapy Journal. 2013,31:1(19-24) doi: 10.1016/j.hkpj.2012.12.003
5. The Effects of Extracorporeal Shockwave Therapy (ESWT) in Treating Lateral Epicondylitis in People between 40 and 50 Years Old. Procedia - Social and Behavioral Sciences. 2014,137(32-36). doi : 10.1016/j.sbspro.2014.05.248
6. Electromagnetic transduction therapy and shockwave therapy in 86 patients with rotator cuff tendinopathy: A prospective randomized controlled trial. Electromagnetic Biology and Medicine. 2018,37:4(175-183). doi : 10.1080/15368378.2018.1499030
PUNHO

1. Comparison of single-dose radial extracorporeal shock wave and local corticosteroid injection for treatment of carpal tunnel syndrome including mid-term efficacy: A prospective randomized controlled trial. BMC Musculoskeletal Disorders. 2018,19:1(1-9) doi : 10.1186/s12891-018-1948-3
2. Effect of radial shock wave therapy for carpal tunnel syndrome: A prospective randomized, double-blind, placebo-controlled trial. Journal of Orthopaedic Research. 2016,34:6 (977-984). doi : 10.1002/jor.23113
3. Application of ESWT in post-operative treatment in Carpal Tunnel Syndrome – a review. 2020, 92:3
MÃO

1.Treatment of scaphoid waist nonunion by one, two headless compression screws or plate with or without additional extracorporeal shockwave therapy. Archives of Orthopaedic and Trauma Surgery. 2019,139:2(281-293). doi : 10.1007/s00402-018-3087-6
2. Extracorporeal shock wave therapy versus corticosteroid injection in the treatment of trigger finger: A randomized controlled study. Journal of Hand Surgery: European Volume. 2016, 41:9(977-983).  doi : 10.1177/1753193415622733
3.Radial extracorporeal shockwave therapy for the treatment of finger tenosynovitis (trigger digit). Open Access Journal of Sports Medicine. 2016,7(143-151) doi : 10.2147/oajsm.s108126
QUADRIL

1. Effectiveness of extracorporeal shock wave monotherapy for avascular necrosis of femoral head: A systematic review protocol of randomized controlled trial. Medicine, 2019,98:14. doi : 10.1097/MD.0000000000015119
2. Extracorporeal shockwave therapy in osteonecrosis of femoral head a systematic review of now available clinical evidences. Medicine (United States), 2017,92:4. doi : 10.1097/MD.0000000000005897
3. Extracorporeal shock wave therapy in the treatment of trochanteric bursitis: the ASSERT database. Muscles, Ligaments & Tendons Journal (MLTJ). 2018,8:3(444-450). doi : 10.11138/mltj/2018.8.3.444
4. Development of Extracorporeal Shockwave Therapy for Treatment of Osteonecrosis of the Femoral Head. Translational Research in Biomedicine. 2018,6(17-26). doi : 10.1159/000485056
5. Effectiveness of various hip preservation treatments for non-traumatic osteonecrosis of the femoral head: A network meta-analysis of randomized controlled trials. Journal of Orthopaedic Science. 2018,23:2(356-364). doi : 10.1016/j.jos.2017.12.004
6. Meta-analysis of the potential role of extracorporeal shockwave therapy in osteonecrosis of the femoral head. Journal of Orthopaedic Surgery and Research. 2018,13:1(1-7). doi : 10.1186/s13018-018-0861-7
7. Radial extracorporeal shock wave therapy in a person with advanced osteonecrosis of the femoral head. American Journal of Physical Medicine and Rehabilitation. 2016,95:9(133-139). doi : 10.1097/PHM.0000000000000484
8. Effects of Focused Extracorporeal Shock Waves on Bone Marrow Mesenchymal Stem Cells in Patients with Avascular Necrosis of the Femoral Head Ultrasound in Medicine and Biology. 2016,42:3(753-762).  doi : 10.1016/j.ultrasmedbio.2015.10.021
JOELHO

1. Therapeutic efficacy of extracorporeal shock wave combined with hyaluronic acid on knee osteoarthritis. Medicine, 2019,98:8. doi : 10.1097/MD.0000000000014589
2. Adult osteochondritis dissecans and focussed ESWT: A successful treatment option. International Journal of Surgery. 2015,24(191-194). doi : 10.1016/j.ijsu.2015.09.035
3. Extracorporeal shock wave therapy in the treatment of patellar tendinopathy: the ASSERT database. Ligaments and Tendons Journal. 2018,8:3(437-443). doi : 10.11138/mltj/2018.8.3.423
4. Extracorporeal shockwave therapy vs. kinesiotherapy for osteoarthritis of the knee: A pilot randomized controlled trial. Journal of Back and Musculoskeletal Rehabilitation. 2017,30:5(1121-1128). doi : 10.3233/BMR-169781
5. Minimally Invasive Interventional Management of Osteoarthritic Chronic Knee Pain. Journal of Knee Surgery. 2019,32:1(72-79)
6. Extracorporeal shock wave treatment can normalize painful bone marrow edema in knee osteoarthritis. Medicine. 2018, 97:5(1-6). doi : 10.1097/MD.0000000000009796
7. A Randomized Controlled Trial on the Effects of Low-Dose Extracorporeal Shockwave Therapy in Patients With Knee Osteoarthritis. Archives of Physical Medicine and Rehabilitation. 2019, 100:9(1695-1702). doi : 10.1016/j.apmr.2019.04.020
8. Clinical efficacy of extracorporeal shockwave therapy for knee osteoarthritis: a systematic review and meta-regression of randomized controlled trials. Clinical Rehabilitation. 2019,33:9(1419-1430). doi : 10.1177/0269215519846942
9. The effect of extracorporeal shock wave therapy on the treatment of moderate to severe knee osteoarthritis and cartilage lesion. Medicine. 2019,98:20. 10.1097/MD.0000000000015523
10. Extracorporeal Shockwave Therapy Accelerates the Healing of a Meniscal Tear in the Avascular Region in a Rat Model. American Journal of Sports Medicine. 2019, 47:12(2937-2944) doi 10.1177/0363546519871059
11. Current concepts of shockwave therapy in chronic patellar tendinopathy. International Journal of Surgery. 2015,24(160-164). 10.1016/j.ijsu.2015.09.066
12. Extracorporeal shockwave therapy for the treatment of knee osteoarthritis. Medicine. 2018,97:27(1-4) doi : 10.1097/MD.0000000000011418
TORNOZELO

1. Shockwave Therapy Associated With Eccentric Strengthening for Achilles Insertional Tendinopathy: A Prospective Study. Foot and Ankle Specialist, 2019,2:16(540-545). doi : 10.1177/1938640019826673
2.Effectiveness of extracorporeal shockwave therapy for chronic achilles tendinopathy: A randomized clinical trial. 2018,23:1. doi: 10.4103/jrms.JRMS_413_16
3.Eccentric loading versus eccentric loading plus shock-wave treatment for midportion achilles tendinopathy: A randomized controlled trial. American Journal of Sports Medicine. 2009,37:3(463-470). doi: 10.1177/0363546508326983
4. Shockwave therapy for chronic Achilles tendinopathy. Acta Orthopaedica. 2008,79:2(249-256). doi : 10.1080/17453670710015058
5. Current evidence of extracorporeal shock wave therapy in chronic Achilles tendinopathy. International Journal of Surgery. 2015,24(154-159). doi : 10.1016/j.ijsu.2015.07.718
6. Extracorporeal shockwave therapy (ESWT) for refractory Achilles tendinopathy: A prospective audit with 2-year follow up. Foot. 2016,26(23-29). doi : 10.1016/j.foot.2015.08.007

1. Extracorporeal shockwave therapy in diabetic foot ulcers. International Journal of Surgery. 2015,24(207-209) doi : 10.1016/j.ijsu.2015.06.024
2. Extracorporeal shock wave therapy in the management of insertional plantar fasciitis: the ASSERT database. Muscle, Ligaments and Tendons Journal. 2018,8:43(402-408). doi : 10.11138/MLTJ/2018.8.3.402
3. Extracorporeal shock wave therapy in the management of midsubstance plantar fasciitis: the ASSERT database. Muscle, Ligaments and Tendons Journal. 2018,8:43(430-436). doi : 10.11138/MLTJ/2018.8.3.430
4.Comparative effectiveness of radial extracorporeal shockwave therapy and ultrasound-guided local corticosteroid injection treatment for plantar fasciitis. Journal of the American Podiatric Medical Association. 2017,107:3(192-199). doi : 10.7547/14-114
5. Assessment of the efficacy of extracorporeal shockwave therapy for plantar fasciitis with magnetic resonance imaging findings. Journal of the American Podiatric Medical Association. 2018,108:2(100-105). doi : 10.7547/15-106
FRATURAS NÃO-CONSOLIDADAS

1. Extracorporeal shockwave therapy (ESWT) in the treatment of atrophic non-unions of femoral shaft fractures. International Journal of Surgery. 2015,24(131-134). doi : 10.1016/j.ijsu.2015.06.075
2. Extracorporeal shockwave therapy (ESWT) - First choice treatment of fracture non-unions? International Journal of Surgery. 2014,4(179-183). doi : 10.1016/j.ijsu.2015.10.003
3. Effects of Extracorporeal Shock Wave Therapy on Fracture Nonunions. Am J Orthop. 2012,41:9(E122-E127). 
4. Focused high-energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture-related infection. Journal of Orthopaedic Research. 2020, 38:6.
5. Combined treatment with extracorporeal shock-wave therapy and bone marrow mesenchymal stem cell transplantation improves bone repair in a rabbit model of bone nonunion. Molecular Medicine Reports. 2018,17:1(1326-1332). doi : 10.3892/mmr.2017.7984
6. Radial extracorporeal shock wave therapy is efficient and safe in the treatment of fracture nonunions of superficial bones: A retrospective case series. Journal of Orthopaedic Surgery and Research. 2017,12:1(1-10). doi : 10.1186/s13018-017-0667-z
7. A novel bimodal approach for treating atrophic bone non-unions with extracorporeal shockwaves and autologous mesenchymal stem cell transplant. Medical Hypotheses. 2018,111(4-7). doi : 10.1016/j.mehy.2017.12.013
8. Significance of Extracorporeal Shockwave Therapy in Fracture Treatment. Transl Res Biomed. 2018,6(42-63). doi : 10.1159/000485061
FRATURAS POR ESTRESS
1. Treatment of Medial Tibial Stress Syndrome With Radial Soundwave Therapy in Elite Athletes: Current Evidence, Report on Two Cases, and Proposed Treatment Regimen. Journal of Foot and Ankle Surgery. 2017,56:5(985-989).
2. Current concepts of shockwave therapy in stress fractures. International Journal of Surgery. 2015,24(195-200). doi : 10.1016/j.ijsu.2015.07.723
3. Shockwave treatment for medial tibial stress syndrome in military cadets: A single-blind randomized controlled trial. International Journal of Surgery. 2017,46(102-109). doi : 10.1016/j.ijsu.2017.08.584
MODULAÇÃO DA INFLAMAÇÃO

1. Effect of shock waves on macrophages: A possible role in tissue regeneration and remodeling. International Journal of Surgery. 2015,24(124-130) doi : 10.1016/j.ijsu.2015.07.719
2. Effect of Extracorporeal Shockwave on Angiogenesis and Anti-Inflammation: Molecular-Cellular Signaling Pathways. Translational Research in Biomedicine. 2018,6(109-116). doi : 10.1159/000485068
CELULITE, QUEIMADURAS, CICATRIZES

1. Effectiveness of the Electromagnetic Shock Wave Therapy in the Treatment of Cellulite. Dermatology Research and Practice. 2019(1-6). doi: 10.1155/2019/8246815
2. Impacts of low-energy extracorporeal shockwave therapy on pain, pruritus, and health-related quality of life in patients with burn: A randomized placebo-controlled study. Burns. 2019,45:5(1094-1101). doi : 10.1016/j.burns.2019.02.007
3.Extracorporeal shock wave therapy (ESWT) for the treatment of cellulite - A current metaanalysis. International Journal of Surgery. 2015,24(210-217). 10.1016/j.ijsu.2015.07.644
4. Extracorporeal shockwave therapy for treatment of keloid scars. Wound Repair and Regeneration. 2018, 26:1(69-76). doi: 10.1111/wrr.12610
5.Extracorporeal shock wave therapy with low-energy flux density inhibits hypertrophic scar formation in an animal model. International Journal of Molecular Medicine. 2018,41:4(1931-1938). doi : 10.3892/ijmm.2018.3434
DISFUNÇÃO ERÉTIL

1. Long-term effectiveness and predictors of success of low-intensity shockwave therapy in phosphodiesterase type 5 inhibitors non-responders. 2020. 18:1
2. Comparison of the effects of extracorporeal shock wave therapy and a vacuum erectile device on penile erectile dysfunction: a randomized clinical trial. 2017,96:44. doi : 10.1097/MD.0000000000008414
3.Application of Extracorporeal Shockwave Therapy on Erectile Dysfunction and Lower Urinary Tract Inflammatory Diseases. Translational Research in Biomedicine. 2018,6(127-139). doi : 10.1159/000485070
4. Low-Intensity Shockwave Therapy for Erectile Dysfunction. Sexual Medicine Reviews. 2018,6:4(624-630). doi : 10.1016/j.sxmr.2018.01.002
5. Efficacy and safety of low-intensity shock wave therapy in penile rehabilitation post nerve-sparing radical cystoprostatectomy: a randomized controlled trial. International Urology and Nephrology. 2018,50:11(2007-2014) doi : 10.1007/s11255-018-1987-6
6. Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction in Diabetic Patients. Sexual Medicine Reviews. 2019. doi : 10.1016/j.sxmr.2019.06.007

7. Low-intensity Extracorporeal Shock Wave Treatment Improves Erectile Function: A Systematic Review and Meta-analysis. European Urology. 2017,71:2(223-233). doi : 10.1016/j.eururo.2016.05.050
CARDIOLOGIA
1. Efficacy of cardiac shock wave therapy in patients with stable angina: The design of randomized, triple blind, sham-procedure controlled study. Anatolian Journal of Cardiology. 2018,19:2(100-109). doi : 10.14744/AnatolJCardiol.2017.8023
2. Cardiac shock wave therapy improves myocardial perfusion and preserves left ventricular mechanics in patients with refractory angina: A study with speckle tracking echocardiography. Echocardiography. 2018,35:10(1564-1570). doi : 10.1111/echo.14054
3. Cardiac Shock Wave Therapy Attenuates Cardiomyocyte Apoptosis after Acute Myocardial Infarction in Rats. Cellular Physiology and Biochemistry. 2018,49:5(1734-1746). doi : 10.1159/000493616
4. Shock Wave Therapy Promotes Cardiomyocyte Autophagy and Survival during Hypoxia. Cellular Physiology and Biochemistry. 2017,42:2(673-684). doi : 10.1159/000477885 
5. Preclinical and Clinical Application of Extracorporeal Shockwave for Ischemic Cardiovascular Disease. 2018,6(87-101). doi : 10.1159/0004850646. Reducer, extracorporeal shockwave therapy or stem cells in refractory angina: A retrospective study. Journal of Cardiovascular Medicine. 2018,19:1(42-44).  doi : 10.2459/JCM.0000000000000577
6. A multicenter trial of extracorporeal cardiac shock wave therapy for refractory angina pectoris: report of the highly advanced medical treatment in Japan. Heart and Vessels. 2019,34:1(104-113). doi : 10.1007/s00380-018-1215-4
7. Shockwave therapy of the heart. International Journal of Surgery. 2015,24(218-222). 10.1016/j.ijsu.2015.09.070
INSUFICIÊNCIAS VASCULARES E FERIDAS CRÔNICAS
1. Extracorporeal shock wave therapy for chronic wounds: A systematic review and meta-analysis of randomized controlled trials. Wound Repair and Regeneration. 2017,25:4(697-706).
2. Randomized, controlled clinical pilot study of venous leg ulcers treated with using two types of shockwave therapy. International Journal of Medical Sciences. 2018,15:12(1275-1285). doi : 10.7150/ijms.26614
3. Extracorporeal shockwave therapy for the treatment of chronic wound of lower extremity: current perspective and systematic review. International Wound Journal. 2017,14:6(898-908). doi : 10.1111/iwj.12723
4. Extracorporeal Shockwave Therapy for Peripheral Arterial Disease: A Review of the Potential Mechanisms of Action. Annals of Vascular Surgery. 2017,45(294-298). doi : 10.1016/j.avsg.2017.06.133
5. Extracorporeal shockwave therapy for intermittent claudication: Medium-term outcomes from a double-blind randomised placebo-controlled pilot trial. Vascular. 2018,26:5(531-539). doi : 10.1177/1708538118773618
6. Extracorporeal shock wave therapy (ESWT) for wound healing: Technology, mechanisms, and clinical efficacy. Wound Repair and Regeneration. 2012,20:4(456-465). doi : 10.1111/j.1524-475X.2012.00796.x
7. The effectiveness of extracorporeal shock wave therapy for the treatment of lower limb ulceration: A systematic review. Journal of Foot and Ankle Research. 2015,8:1. doi : 10.1186/s13047-014-0059-0
REGENERAÇÃO NEUROLÓGICA E ESPASTICIDADE
1. Effect of extracorporeal shock wave therapy on lower limb spasticity in stroke patients. Archives of Iranian Medicine. 2017,20:6(338-343). 

2. Extracorporeal shockwave therapy enhances peripheral nerve remyelination and gait function in a crush model. Advances in Clinical and Experimental Medicine. 2020, 29:7
3. Rehabilitation treatment of spastic cerebral palsy with radial extracorporeal shock wave therapy and rehabilitation therapy. Medicine (United States). 2018,97:51(1-5). doi : 10.1097/MD.0000000000013828
4. Clinical study of combined mirror and extracorporeal shock wave therapy on upper limb spasticity in poststroke patients. International Journal of Rehabilitation Research. 2019,42:1(31-35) doi : 10.1097/MRR.0000000000000316
5. Shock wave therapy for spastic plantar flexor muscles in hemiplegic cerebral palsy children. Egyptian Journal of Medical Human Genetics. 2015,16:3(269-275). doi : 10.1016/j.ejmhg.2014.12.007

Dr. Otávio Melo
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- Respostas terapêuticas dependem de múltiplas variáveis e características biológicas individuais de cada organismo. Os dados apresentados não configuram promessas de resultado, e nem garantias de que se o mesmo método for aplicado em pessoas diferentes alcançarão os mesmos benefícios.
- As informações contidas nesse site são de caráter meramente informativo e não tem como objetivo substituir consultas médicas, avaliação por profissionais de saúde, nem sugerir diagnósticos ou recomendação para tratamentos específicos.
- Os métodos apresentados possuem referências em artigos publicaods na literatura científica internacional, e  podem corresponder tanto a procedimentos regulamentados quando experimentais, de acordo com a regulamentação dos respectivos Conselhos Federais, à época do acesso, no Brasil.
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